Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles-Reference-Cited by-同舟云学术

Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles

Published:2019-11 Issue:41 Volume:4 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Petrova Velislava N.¹^ORCID,Sawatsky Bevan²^ORCID,Han Alvin X.³⁴,Laksono Brigitta M.⁵,Walz Lisa²,Parker Edyth⁴^ORCID,Pieper Kathrin⁶^ORCID,Anderson Carl A.¹^ORCID,de Vries Rory D.⁵,Lanzavecchia Antonio⁶^ORCID,Kellam Paul⁷⁸^ORCID,von Messling Veronika²^ORCID,de Swart Rik L.⁵^ORCID,Russell Colin A.⁴^ORCID

Affiliation:

1. Department of Human Genetics, Wellcome Sanger Institute, Cambridge, UK.

2. Veterinary Medicine Division, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines and DZIF TTU Emerging Infections, Langen, Germany.

3. Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

4. Laboratory of Applied Evolutionary Biology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.

5. Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, Netherlands.

6. Institute for Research in Biomedicine, Università della Svizzera Italiana, Bellinzona, Switzerland.

7. Department of Medicine, Division of Infectious Diseases, Imperial College Faculty of Medicine, Wright Fleming Institute, St Mary’s Campus, London, UK.

8. Kymab Ltd., The Bennet Building, Babraham Research Campus, Cambridge, UK.

Abstract

Measles causes immunosuppression by restricting naïve B cell diversity and eliminating previously established B memory cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference54 articles.

1. World Health Organization Measles; https://www.who.int/news-room/fact-sheets/detail/measles.

2. Global measles elimination

3. The pathogenesis of measles

4. Immune Activation in Measles

5. Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality

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