Early cross-coronavirus reactive signatures of humoral immunity against COVID-19

Author:

Kaplonek Paulina1,Wang Chuangqi2ORCID,Bartsch Yannic1ORCID,Fischinger Stephanie1ORCID,Gorman Matthew J.1,Bowman Kathryn1ORCID,Kang Jaewon1,Dayal Diana3ORCID,Martin Patrick3,Nowak Radoslaw P.45ORCID,Villani Alexandra-Chloé6789ORCID,Hsieh Ching-Lin10ORCID,Charland Nicole C.11ORCID,Gonye Anna L.K.67ORCID,Gushterova Irena67ORCID,Khanna Hargun K.11ORCID,LaSalle Thomas J.67ORCID,Lavin-Parsons Kendall M.11,Lilley Brendan M.11ORCID,Lodenstein Carl L.11,Manakongtreecheep Kasidet69,Margolin Justin D.11ORCID,McKaig Brenna N.11ORCID,Rojas-Lopez Maricarmen81213,Russo Brian C.81213ORCID,Sharma Nihaarika67,Tantivit Jessica69,Thomas Molly F.678914ORCID,Sade-Feldman Moshe678ORCID,Feldman Jared1ORCID,Julg Boris1ORCID,Nilles Eric J.15,Musk Elon R.3,Menon Anil S.3,Fischer Eric S.4511ORCID,McLellan Jason S.10ORCID,Schmidt Aaron1ORCID,Goldberg Marcia B.681216ORCID,Filbin Michael R.611ORCID,Hacohen Nir678ORCID,Lauffenburger Douglas A.2ORCID,Alter Galit1ORCID

Affiliation:

1. Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.

2. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

3. Space Exploration Technologies Corporation, Hawthorne, CA, USA.

4. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.

5. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

6. Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.

7. Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

8. Department of Medicine, Harvard Medical School, Boston, MA, USA.

9. Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

10. Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.

11. Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA.

12. Department of Microbiology, Harvard Medical School, Boston, MA, USA.

13. Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

14. Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

15. Brigham and Women’s Hospital, Boston, MA, USA.

16. Department of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Boston, MA, USA.

Abstract

Preexisting cross-coronavirus immunity influences the early development of SARS-CoV-2 humoral immunity after COVID-19.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference81 articles.

1. An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

2. Oxford–AstraZeneca COVID-19 vaccine efficacy

3. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

4. SARS-CoV-2 mRNA vaccines induce a greater array of spike-specific antibody isotypes with more potent complement binding capacity than natural infection;Klingler J.;medRxiv,2021

5. Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies

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