Clonal expansion and activation of tissue-resident memory-like T H 17 cells expressing GM-CSF in the lungs of patients with severe COVID-19-Reference-Cited by-同舟云学术

Clonal expansion and activation of tissue-resident memory-like T H 17 cells expressing GM-CSF in the lungs of patients with severe COVID-19

Published:2021-02-12 Issue:56 Volume:6 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Zhao Yu¹²³⁴^ORCID,Kilian Christoph¹^ORCID,Turner Jan-Eric³⁵,Bosurgi Lidia⁶⁷,Roedl Kevin⁸^ORCID,Bartsch Patricia¹^ORCID,Gnirck Ann-Christin³⁵,Cortesi Filippo⁶^ORCID,Schultheiß Christoph⁹^ORCID,Hellmig Malte¹^ORCID,Enk Leon U.B.¹^ORCID,Hausmann Fabian²^ORCID,Borchers Alina¹,Wong Milagros N.⁵,Paust Hans-Joachim¹,Siracusa Francesco⁶,Scheibel Nicola⁶^ORCID,Herrmann Marissa⁶^ORCID,Rosati Elisa¹⁰,Bacher Petra¹⁰¹¹,Kylies Dominik⁵,Jarczak Dominik⁸^ORCID,Lütgehetmann Marc¹²^ORCID,Pfefferle Susanne¹²^ORCID,Steurer Stefan¹³,Schulze zur Wiesch Julian⁶^ORCID,Puelles Victor G.⁵^ORCID,Sperhake Jan-Peter¹⁴,Addo Marylyn M.¹⁵¹⁶^ORCID,Lohse Ansgar W.⁶,Binder Mascha⁹,Huber Samuel³⁶^ORCID,Huber Tobias B.³⁵^ORCID,Kluge Stefan⁸,Bonn Stefan²³⁴^ORCID,Panzer Ulf¹³,Gagliani Nicola³⁶¹⁷¹⁸^ORCID,Krebs Christian F.¹³^ORCID

Affiliation:

1. III. Department of Medicine, Division of Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

2. Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

3. Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

4. Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

5. III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

6. I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

7. Protozoa Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.

8. Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

9. Department of Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.

10. Institute of Clinical Molecular Biology, Christian-Albrechts University of Kiel, Kiel, Germany.

11. Institute of Immunology, Christian-Albrechts-University of Kiel and UKSH Schleswig-Holstein, Kiel, Germany.

12. Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

13. Institute for Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

14. Department of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

15. I. Department of Medicine, Division of Infectious Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

16. German Center for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.

17. Department for General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

18. Immunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University Hospital, Stockholm, Sweden.

Abstract

Tissue-resident memory-like T H 17 cells are clonally expanded in bronchoalveolar lavage fluid of patients with severe COVID-19.

Funder

Deutsches Zentrum für Infektionsforschung

H2020 European Research Council

Deutsche Forschungsgemeinschaft

Bundesministerium für Bildung und Forschung

Else Kröner-Fresenius-Stiftung

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference46 articles.

1. An interactive web-based dashboard to track COVID-19 in real time

2. Dexamethasone in Hospitalized Patients with Covid-19

3. GM-CSF Neutralization With Lenzilumab in Severe COVID-19 Pneumonia

4. GM-CSF blockade with mavrilimumab in severe COVID-19 pneumonia and systemic hyperinflammation: a single-centre, prospective cohort study

5. Anakinra for severe forms of COVID-19: a cohort study

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