Type I interferon responses drive intrahepatic T cells to promote metabolic syndrome

Author:

Ghazarian Magar12ORCID,Revelo Xavier S.1ORCID,Nøhr Mark K.1ORCID,Luck Helen12ORCID,Zeng Kejing13,Lei Helena1ORCID,Tsai Sue1,Schroer Stephanie A.1ORCID,Park Yoo Jin1ORCID,Chng Melissa Hui Yen4ORCID,Shen Lei5,D’Angelo June Ann6ORCID,Horton Peter78ORCID,Chapman William C.9,Brockmeier Diane10ORCID,Woo Minna1,Engleman Edgar G.4ORCID,Adeyi Oyedele1112ORCID,Hirano Naoto213ORCID,Jin Tianru1ORCID,Gehring Adam J.614,Winer Shawn11215,Winer Daniel A.121112

Affiliation:

1. Division of Cellular and Molecular Biology, Diabetes Research Group, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario M5G 1L7, Canada.

2. Department of Immunology, University of Toronto, 1 King’s College Circle, Toronto, Ontario M5S 3B3, Canada.

3. Department of Endocrinology and Metabolism, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.

4. Department of Pathology, Stanford University School of Medicine, Palo Alto, CA 94205, USA.

5. Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China.

6. Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.

7. Methodist University Hospital Transplant Institute, Memphis, TN 38104, USA.

8. Division of Abdominal Transplant, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.

9. Division of Abdominal Transplant, Washington University School of Medicine, St. Louis, MO 63110, USA.

10. Mid-America Transplant Services, St. Louis, MO 63110, USA.

11. Department of Pathology, University Health Network, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada.

12. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

13. Campbell Family Cancer Research Institute, University Health Network, Toronto, Ontario M5G 2M9, Canada.

14. Toronto Centre for Liver Disease, University Health Network, Toronto, Ontario M5G 2C4, Canada.

15. Department of Laboratory Medicine, St. Michael’s Hospital, Toronto, Ontario M5B 1W8, Canada.

Abstract

Obesity-related insulin resistance correlates with type I interferon–driven activation and expansion of intrahepatic T cells. See the related Focus by Ma et al .

Funder

CIHR

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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