CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration

Author:

Xiong Yanbao12ORCID,Piao Wenji12ORCID,Brinkman C. Colin2,Li Lushen12ORCID,Kulinski Joseph M.3ORCID,Olivera Ana3,Cartier Andreane45ORCID,Hla Timothy45ORCID,Hippen Keli L.6ORCID,Blazar Bruce R.6ORCID,Schwab Susan R.7,Bromberg Jonathan S.128

Affiliation:

1. Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

2. Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

3. Mast Cell Biology Section, Laboratory of Allergic Diseases, NIAID, NIH, Bethesda, MD 20892, USA.

4. Vascular Biology Program, Boston Children’s Hospital, Boston, MA 20115, USA.

5. Department of Surgery, Harvard Medical School, Boston, MA 20115, USA.

6. University of Minnesota Cancer Center and the Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA.

7. Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.

8. Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Abstract

Sphingosine 1-phosphate engages multiple T cell and lymphatic endothelial cell receptors to regulate lymphocyte migration.

Funder

NIH Office of the Director

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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