Early precursors and molecular determinants of tissue-resident memory CD8 + T lymphocytes revealed by single-cell RNA sequencing

Author:

Kurd Nadia S.1ORCID,He Zhaoren23ORCID,Louis Tiani L.1ORCID,Milner J. Justin3ORCID,Omilusik Kyla D.3ORCID,Jin Wenhao2,Tsai Matthew S.1ORCID,Widjaja Christella E.1ORCID,Kanbar Jad N.1,Olvera Jocelyn G.1ORCID,Tysl Tiffani1ORCID,Quezada Lauren K.1ORCID,Boland Brigid S.1ORCID,Huang Wendy J.2ORCID,Murre Cornelis3ORCID,Goldrath Ananda W.3,Yeo Gene W.24,Chang John T.15ORCID

Affiliation:

1. Department of Medicine, University of California San Diego, La Jolla, CA, USA.

2. Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.

3. Division of Biologic Sciences, University of California San Diego, La Jolla, CA, USA.

4. Institute for Genomic Medicine, University of California San Diego, La Jolla, California, USA.

5. Division of Gastroenterology, VA San Diego Healthcare System, San Diego, CA, USA.

Abstract

Heterogeneity of small intestine intraepithelial CD8 + T cells suggests functionally distinct subsets of T RM cells and their precursors.

Funder

National Institutes of Health

National Institute of Mental Health

National Institute of Allergy and Infectious Diseases

National Institute of Diabetes and Digestive and Kidney Diseases

National Center for Advancing Translational Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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