Natural killer cell–mediated inflammation resolution is disabled in severe asthma

Author:

Duvall Melody G.12ORCID,Barnig Cindy3ORCID,Cernadas Manuela1ORCID,Ricklefs Isabell1,Krishnamoorthy Nandini1,Grossman Nicole L.1,Bhakta Nirav R.4ORCID,Fahy John V.4ORCID,Bleecker Eugene R.5,Castro Mario6ORCID,Erzurum Serpil C.7,Gaston Benjamin M.8,Jarjour Nizar N.9ORCID,Mauger David T.10ORCID,Wenzel Sally E.11ORCID,Comhair Suzy A.7,Coverstone Andrea M.12ORCID,Fajt Merritt L.11ORCID,Hastie Annette T.5,Johansson Mats W.13ORCID,Peters Michael C.4ORCID,Phillips Brenda R.10,Israel Elliot1,Levy Bruce D.1ORCID,

Affiliation:

1. Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

2. Division of Critical Care Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

3. Department of Chest Diseases, University Hospital of Strasbourg, Strasbourg, France.

4. Division of Pulmonary and Critical Care Medicine, Department of Medicine and the Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.

5. Center for Genomics and Personalized Medicine Research, School of Medicine, Wake Forest University, Winston-Salem, NC 27157, USA.

6. Division of Pulmonary and Critical Care Medicine, Departments of Medicine and Pediatrics, Washington University, St. Louis, MO 63110, USA.

7. Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

8. Department of Pediatrics, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, OH 44106, USA.

9. Division of Allergy, Pulmonary, and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.

10. Division of Statistics and Bioinformatics, Department of Public Health Sciences, Pennsylvania State University, Hershey, PA 17033, USA.

11. Pulmonary, Allergy and Critical Care Medicine Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

12. Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.

13. Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA.

Abstract

Severe asthma is characterized by decreased NK cell cytotoxicity, and corticosteroids further disable NK cell function.

Funder

National Heart, Lung, and Blood Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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