Contribution of resident and circulating precursors to tumor-infiltrating CD8 + T cell populations in lung cancer

Author:

Gueguen Paul1ORCID,Metoikidou Christina1ORCID,Dupic Thomas2ORCID,Lawand Myriam1,Goudot Christel1,Baulande Sylvain3ORCID,Lameiras Sonia3,Lantz Olivier14ORCID,Girard Nicolas5,Seguin-Givelet Agathe67ORCID,Lefevre Marine6,Mora Thierry8ORCID,Walczak Aleksandra M.9ORCID,Waterfall Joshua J.1011ORCID,Amigorena Sebastian1ORCID

Affiliation:

1. PSL Research University, Institut Curie Research Center, INSERM U932, Paris, France.

2. Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.

3. Institut Curie Genomics of Excellence (ICGex) Platform, Institut Curie Research Center, Paris, France.

4. Centre d’Investigation Clinique Biothérapie, Institut Curie, Paris, France.

5. Institut Curie, Institut du Thorax Curie Montsouris, Paris, France.

6. Institut Montsouris, Surgery Department, Institut du Thorax Curie Montsouris, Paris, France.

7. Paris 13 University, Sorbonne Paris Cité, Faculty of Medicine SMBH, Bobigny, France.

8. PSL Research University, Laboratoire de physique statistique, CNRS, Sorbonne Université, Université Paris Diderot, Paris, France.

9. PSL Research University, Laboratoire de physique théorique, CNRS, Sorbonne Université, Université Paris Diderot, and École normale supérieure, Paris, France.

10. PSL Research University, Institut Curie Research Center, INSERM U830, Paris, France.

11. PSL Research University, Institut Curie Research Center, Department of Translational Research, Paris, France.

Abstract

CD8 + T cells in lung tumors differentiate through convergent pathways to an expanded and actively cycling terminal state.

Funder

European Research Council

Agence Nationale de la Recherche

Fondation ARC pour la Recherche sur le Cancer

Institut Curie

Janssen Horizon

Fondation Chercher et Trouver

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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