Autophagy protects tumors from T cell–mediated cytotoxicity via inhibition of TNFα-induced apoptosis-Reference-Cited by-同舟云学术

Autophagy protects tumors from T cell–mediated cytotoxicity via inhibition of TNFα-induced apoptosis

Published:2020-12-18 Issue:54 Volume:5 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Young Tara M.¹^ORCID,Reyes Claudia¹^ORCID,Pasnikowski Elizabeth¹,Castanaro Carla¹,Wong Chung¹^ORCID,Decker Corinne E.¹,Chiu Joyce¹^ORCID,Song Hang¹,Wei Yi¹,Bai Yu¹,Zambrowicz Brian¹,Thurston Gavin¹,Daly Christopher¹^ORCID

Affiliation:

1. Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.

Abstract

Autophagy reduces tumor cell sensitivity to T cell killing; thus, inhibiting autophagy may improve T cell–engaging therapies.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference58 articles.

1. Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy

2. Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

3. Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

4. Tumor immune evasion arises through loss of TNF sensitivity

5. In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

Cited by 71 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Baicalin induces cell death of non-small cell lung cancer cells via MCOLN3-mediated lysosomal dysfunction and autophagy blockage;Phytomedicine;2024-10

2. GRB7 Plays a Vital Role in Promoting the Progression and Mediating Immune Evasion of Ovarian Cancer;Pharmaceuticals;2024-08-07

3. Deciphering the Effects of the PYCR Family on Cell Function, Prognostic Value, Immune Infiltration in ccRCC and Pan-Cancer;International Journal of Molecular Sciences;2024-07-25

4. Nanotherapeutics targeting autophagy regulation for improved cancer therapy;Acta Pharmaceutica Sinica B;2024-06

5. XPR1 promotes ovarian cancer growth and regulates MHC-I through autophagy;2024-04-24