Targeting Piezo1 unleashes innate immunity against cancer and infectious disease-Reference-Cited by-同舟云学术

Targeting Piezo1 unleashes innate immunity against cancer and infectious disease

Published:2020-08-14 Issue:50 Volume:5 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Aykut Berk¹^ORCID,Chen Ruonan¹^ORCID,Kim Jacqueline I.¹,Wu Dongling¹,Shadaloey Sorin A. A.¹,Abengozar Raquel¹,Preiss Pamela¹,Saxena Anjana²³^ORCID,Pushalkar Smruti⁴^ORCID,Leinwand Joshua¹,Diskin Brian¹,Wang Wei¹,Werba Gregor¹^ORCID,Berman Matthew¹^ORCID,Lee Steve Ki Buom¹,Khodadadi-Jamayran Alireza⁵^ORCID,Saxena Deepak⁴⁶^ORCID,Coetzee William A.⁷⁸⁹,Miller George¹¹⁰^ORCID

Affiliation:

1. S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY 10016, USA.

2. Biology Department, Brooklyn College, New York, NY 11210, USA.

3. Biology/Biochemistry Programs, Graduate Center (CUNY), New York, NY 10016, USA.

4. Department of Basic Science and Craniofacial Biology, NYU College of Dentistry, New York, NY 10010, USA.

5. Applied Bioinformatics Laboratories, NYU School of Medicine, New York, NY 10016, USA.

6. Department of Microbiology and Immunology, New York University School of Medicine, New York, NY 10016, USA.

7. Department of Pediatrics, New York University School of Medicine, New York, NY 10016, USA.

8. Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA.

9. Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.

10. Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA.

Abstract

Blockade of the Piezo1 mechanoreceptor decreases myeloid cell suppression of immune responses to cancer and polymicrobial sepsis.

Funder

National Science Foundation

National Institutes of Health

U.S. Department of Defense

Deutsche Forschungsgemeinschaft

Damon Runyon Cancer Research Foundation

V Foundation for Cancer Research

Mary Kay Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference65 articles.

1. Mechanically Activated Ion Channels

2. Piezo-Electrically Driven Mechanical Stimulation of Sensory Neurons

3. Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

4. Piezo2 is required for Merkel-cell mechanotransduction

5. Piezo1, a mechanically activated ion channel, is required for vascular development in mice

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