CTLA-4–mediated transendocytosis of costimulatory molecules primarily targets migratory dendritic cells-Reference-Cited by-同舟云学术

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CTLA-4–mediated transendocytosis of costimulatory molecules primarily targets migratory dendritic cells

Published:2019-05-24 Issue:35 Volume:4 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Ovcinnikovs Vitalijs¹,Ross Ellen M.¹^ORCID,Petersone Lina¹^ORCID,Edner Natalie M.¹^ORCID,Heuts Frank¹^ORCID,Ntavli Elisavet¹,Kogimtzis Alexandros¹,Kennedy Alan¹,Wang Chun Jing¹,Bennett Clare L.¹²^ORCID,Sansom David M.¹,Walker Lucy S. K.¹^ORCID

Affiliation:

1. Institute of Immunity and Transplantation, University College London Division of Infection and Immunity, Royal Free Campus, NW3 2PF London , UK.

2. Department of Haematology, University College London Cancer Institute, Royal Free Campus, NW3 2PF London, UK.

Abstract

CTLA-4 transendocytosis is elicited by self-antigens and down-regulates costimulatory ligands on migratory dendritic cells.

Funder

Medical Research Council

Diabetes UK

Rosetrees Trust

Horizon 2020

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference63 articles.

1. Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4

2. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4;Tivol E. A.;Immunity,1995

3. CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms;Ise W.;Nat. Immunol.,2010

4. Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4

5. Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations

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