Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individuals-Reference-Cited by-同舟云学术

Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individuals

Published:2021-06-15 Issue:60 Volume:6 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Jin Jun¹²^ORCID,Kim Chulwoo¹²^ORCID,Xia Qiong¹,Gould Timothy M.¹²^ORCID,Cao Wenqiang¹²^ORCID,Zhang Huimin¹²^ORCID,Li Xuanying¹²,Weiskopf Daniela³^ORCID,Grifoni Alba³^ORCID,Sette Alessandro³⁴^ORCID,Weyand Cornelia M.¹²^ORCID,Goronzy Jorg J.¹²^ORCID

Affiliation:

1. Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, USA.

2. Department of Medicine, Palo Alto Veterans Administration Healthcare System, Palo Alto, CA, United States.

3. Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA.

4. Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, CA, USA.

Abstract

Sustained activation of mTORC1 at late endosomes in primary CD4 + T cell responses of older individuals impairs T helper cell function.

Funder

National Institutes of Health

National Institute on Aging

National Institute of Allergy and Infectious Diseases

National Institutes of Health contract Nr

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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