Epigenomics of human CD8 T cell differentiation and aging

Author:

Moskowitz David M.12ORCID,Zhang David W.134,Hu Bin34ORCID,Le Saux Sabine34ORCID,Yanes Rolando E.34ORCID,Ye Zhongde34ORCID,Buenrostro Jason D.15ORCID,Weyand Cornelia M.34ORCID,Greenleaf William J.1ORCID,Goronzy Jörg J.34ORCID

Affiliation:

1. Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.

2. Biomedical Informatics Training Program, Stanford University School of Medicine, Stanford, CA 94305, USA.

3. Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA 94305, USA.

4. Department of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94306, USA.

5. Program in Epithelial Biology and the Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

Genome-wide epigenetic profiling defines the transcriptional networks involved in T cell aging.

Funder

National Institutes of Health

Rita Allen Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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