The double-edged sword: Harnessing PD-1 blockade in tumor and autoimmunity-Reference-Cited by-同舟云学术

The double-edged sword: Harnessing PD-1 blockade in tumor and autoimmunity

Published:2021-11-26 Issue:65 Volume:6 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Kuchroo Juhi R.¹²^ORCID,Hafler David A.³⁴^ORCID,Sharpe Arlene H.¹²⁴⁵^ORCID,Lucca Liliana E.³^ORCID

Affiliation:

1. Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.

2. Evergrande Center for Immunological Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA.

3. Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT, USA.

4. Broad Institute of MIT and Harvard University, Cambridge, MA, USA.

5. Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.

Abstract

PD-1 restrains both effector T cells and T regs ; therefore, PD-1 may be uniquely modulated to enhance tumor rejection while maintaining immune tolerance.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference194 articles.

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