Protection against autoimmunity is driven by thymic epithelial cell–mediated regulation of T reg development-Reference-Cited by-同舟云学术

Protection against autoimmunity is driven by thymic epithelial cell–mediated regulation of T reg development

Published:2021-11-26 Issue:65 Volume:6 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Haftmann Claudia¹^ORCID,Zwicky Pascale¹^ORCID,Ingelfinger Florian¹,Mair Florian¹²^ORCID,Floess Stefan³^ORCID,Riedel René⁴^ORCID,Durek Pawel⁴^ORCID,Spalinger Marianne R.⁵^ORCID,Friebel Ekaterina¹^ORCID,Leung Brian P.⁶^ORCID,Lutz Mirjam¹^ORCID,Puertas Nicole¹,Amorim Ana¹^ORCID,Schärli Stefanie¹^ORCID,Becher Benedict¹,Kisielow Jan⁷^ORCID,Waisman Ari⁸^ORCID,Mashreghi Mir-Farzin⁴⁹^ORCID,Huehn Jochen³¹⁰,Becher Burkhard¹^ORCID

Affiliation:

1. Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.

2. Division of Vaccine and Infectious Disease, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

3. Helmholtz Centre for Infection Research, Experimental Immunology, Braunschweig, Germany.

4. Therapeutic Gene Regulation, Deutsches Rheuma-Forschungszentrum, Berlin, Germany.

5. Universitätsspital, Klinik für Gastroenterologie und Hepatologie, Zürich, Switzerland.

6. Department of Physiology and Biophysics, University of Southern California, Los Angeles, CA, USA.

7. Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Zürich, Switzerland.

8. Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

9. Berlin Institute of Health (BIH), Charité Universitätsmedizin Berlin, Berlin, Germany.

10. Hannover Medical School, Hannover, Germany.

Abstract

Thymic education of regulatory T cells is more important than negative selection in the prevention of autoimmunity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference76 articles.

1. Clonal deletion of Vβ5+ T cells by transgenic I-E restricted to thymic medullary epithelium;Burkly L. C.;J. Immunol.,1993

2. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

3. Presence in peripheral blood of healthy individuals of autoreactive T cells to a membrane antigen present on bone marrow-derived cells

4. Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

5. Impaired thymic negative selection causes autoimmune graft-versus-host disease

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