NF-κB–dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity

Author:

Ghislat Ghita1ORCID,Cheema Ammar S.1,Baudoin Elodie1,Verthuy Christophe1,Ballester Pedro J.2,Crozat Karine1ORCID,Attaf Noudjoud1ORCID,Dong Chuang1ORCID,Milpied Pierre1ORCID,Malissen Bernard1ORCID,Auphan-Anezin Nathalie1ORCID,Manh Thien P. Vu1ORCID,Dalod Marc1ORCID,Lawrence Toby134ORCID

Affiliation:

1. CNRS, INSERM, Centre d’Immunologie de Marseille-Luminy (CIML), Turing Center for Living Systems, Aix-Marseille University, 13009 Marseille, France.

2. Cancer Research Center of Marseille CRCM, INSERM, Institut Paoli-Calmettes, Aix-Marseille University, CNRS, 13009 Marseille, France.

3. Centre for Inflammation Biology and Cancer Immunology, Cancer Research UK King’s Health Partners Centre, School of Immunology and Microbial Sciences, King’s College London, London SE1 1UL, UK.

4. Henan Key Laboratory of Immunology and Targeted Therapy, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China.

Abstract

NF-κB and IRF1 coordinate intratumoral cDC1 maturation and control of immunogenic tumor growth.

Funder

H2020 Marie Skłodowska-Curie Actions

Agence Nationale de la Recherche

Institut National Du Cancer

Ligue Nationale contre le Cancer

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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