Polyclonal expansion of TCR Vb 21.3 + CD4 + and CD8 + T cells is a hallmark of multisystem inflammatory syndrome in children-Reference-Cited by-同舟云学术

Polyclonal expansion of TCR Vb 21.3 + CD4 + and CD8 + T cells is a hallmark of multisystem inflammatory syndrome in children

Published:2021-05-28 Issue:59 Volume:6 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Moreews Marion¹^ORCID,Le Gouge Kenz²^ORCID,Khaldi-Plassart Samira³⁴,Pescarmona Rémi¹⁴⁵^ORCID,Mathieu Anne-Laure¹,Malcus Christophe⁶⁷^ORCID,Djebali Sophia¹^ORCID,Bellomo Alicia¹^ORCID,Dauwalder Olivier¹⁸^ORCID,Perret Magali¹⁵^ORCID,Villard Marine¹⁵^ORCID,Chopin Emilie⁹,Rouvet Isabelle⁹,Vandenesch Francois¹⁸^ORCID,Dupieux Céline¹⁸^ORCID,Pouyau Robin¹⁰^ORCID,Teyssedre Sonia¹⁰,Guerder Margaux¹⁰,Louazon Tiphaine¹¹^ORCID,Moulin-Zinsch Anne¹²,Duperril Marie¹³^ORCID,Patural Hugues¹³¹⁴,Giovannini-Chami Lisa¹⁵¹⁶,Portefaix Aurélie¹⁷,Kassai Behrouz¹⁷,Venet Fabienne¹⁶^ORCID,Monneret Guillaume⁶⁷^ORCID,Lombard Christine⁵^ORCID,Flodrops Hugues¹⁸^ORCID,De Guillebon Jean-Marie¹⁹,Bajolle Fanny²⁰^ORCID,Launay Valérie²¹,Bastard Paul²²²³^ORCID,Zhang Shen-Ying²²²³²⁴,Dubois Valérie²⁵^ORCID,Thaunat Olivier¹²⁵²⁶²⁷^ORCID,Richard Jean-Christophe²⁸²⁹^ORCID,Mezidi Mehdi²⁸²⁹,Allatif Omran¹^ORCID,Saker Kahina¹³⁰,Dreux Marlène¹^ORCID,Abel Laurent²²²³²⁴^ORCID,Casanova Jean-Laurent²²²³²⁴³¹^ORCID,Marvel Jacqueline¹^ORCID,Trouillet-Assant Sophie¹³⁰^ORCID,Klatzmann David²³²^ORCID,Walzer Thierry¹,Mariotti-Ferrandiz Encarnita²³²^ORCID,Javouhey Etienne⁷¹⁰,Belot Alexandre¹⁶^ORCID

Affiliation:

1. CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon F-69007, France.

2. Sorbonne Université, UPMC Univ Paris 06, INSERM UMRS 959, Immunology Immunopathology-Immunotherapy (i3), Paris, France.

3. Pediatric Nephrology, Rheumatology, Dermatology Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon (RAISE), Lyon, France.

4. National Referee Centre for Rheumatic and AutoImmune and Systemic diseases in childrEn, Lyon, France.

5. Immunology Laboratory, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France.

6. Hospices Civils de Lyon, Edouard Herriot Hospital, Immunology Laboratory, 69437 Lyon, France.

7. EA 7426 “Pathophysiology of Injury-Induced Immunosuppression” (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon - bioMérieux), Joint Research Unit HCL-bioMérieux, 69003 Lyon, France.

8. Centre National de Référence des Staphylocoques, Institut des Agents Infectieux, Hospices Civils de Lyon, F-69004 Lyon, France.

9. Cellular Biotechnology Department and Biobank, Hospices Civils de Lyon, Lyon, France.

10. Réanimation Pédiatrique Hôpital Femme-Mère-Enfant Hospices Civils de Lyon, Bron, France.

11. Service de pédiatrie, Centre Hospitalier de Valence, Valence, France.

12. Unité medico-chirurgicale des cardiopathies congénitales, hôpital Louis-Pradel, hospices civils de Lyon, 69677 Bron, France.

13. Pediatric intensive care unit, University hospital of Saint-Étienne, Saint-Priest-en-Jarez, France.

14. U1059 INSERM - SAINBIOSE - DVH – Université de Saint-Étienne, 42055 Saint-Étienne, France.

15. Pediatric Pulmonology and Allergology Department, Hôpitaux pédiatriques de Nice CHU-Lenval, Nice, France.

16. Université Côte d’Azur, Nice, France.

17. Center of Clinical Investigation, Lyon University Hospital, Bron, France.

18. Service de Pédiatrie, Groupe Hospitalier Sud Réunion, CHU de La Réunion, Saint Pierre, La Réunion, France.

19. Service de Néphrologie, Rhumatologie pédiatrique, Hôpitaux pédiatriques de Nice CHU-Lenval, Nice, France.

20. Hôpital Necker Enfants Malades, Centre de référence M3C, AP-HP, Paris, France.

21. Urgences pédiatriques, Hôpital femme Mère Enfant, Hospices Civils de Lyon, Bron, France.

22. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.

23. University of Paris, Imagine Institute, Paris, France.

24. St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.

25. EFS Auvergne Rhône Alpes, laboratoire Histocompatibilité, 111, rue Elisée-Reclus, 69150 Décines, France.

26. Department of Transplantation, Nephrology, and Clinical Immunology, Edouard Herriot University Hospital, Lyon, France.

27. Lyon-Est Medical Faculty, Claude Bernard University (Lyon 1), 8, avenue Rockfeller, 69373 Lyon, France.

28. Médecine Intensive-Réanimation, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.

29. Lyon University, Lyon, France.

30. Laboratoire de Virologie, Institut des Agents Infectieux, Laboratoire associé au Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France.

31. Howard Hughes Medical Institute, New York, NY, USA.

32. Assistance Publique - Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Biotherapy and Département Hospitalo-Universitaire Inflammation-Immunopathology-Biotherapy (i2B), Paris, France.

Abstract

MIS-C is characterized by a polyclonal activation of Vβ21.3 + CD4 + and CD8 + T cells that poorly respond to SARS-CoV-2 antigens.

Funder

H2020 European Institute of Innovation and Technology

FP7 Ideas: European Research Council

Agence Nationale de la Recherche

Fondation hospices Civils de Lyon

Olympic Lyonnais Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology