IL-23 and IL-2 activation of STAT5 is required for optimal IL-22 production in ILC3s during colitis-Reference-Cited by-同舟云学术

IL-23 and IL-2 activation of STAT5 is required for optimal IL-22 production in ILC3s during colitis

Published:2020-04-03 Issue:46 Volume:5 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Bauché David¹^ORCID,Joyce-Shaikh Barbara¹,Fong Julie¹^ORCID,Villarino Alejandro V.²^ORCID,Ku Karin S.¹^ORCID,Jain Renu¹^ORCID,Lee Yu-chi¹^ORCID,Annamalai Lakshmanan¹,Yearley Jennifer H.¹,Cua Daniel J.

Affiliation:

1. Merck & Co. Inc., Merck Research Laboratories, Palo Alto, CA 94304-1104, USA.

2. Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Cooperation between STAT5 and STAT3 enables maximal induction of IL-22 in ILC3s.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference49 articles.

1. A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R

2. Identification and purification of human stat proteins activated in response to interleukin-2

3. Functional Activation of Jak1 and Jak3 by Selective Association with IL-2 Receptor Subunits

4. Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation

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