Helicobacter species are potent drivers of colonic T cell responses in homeostasis and inflammation

Author:

Chai Jiani N.1ORCID,Peng Yangqing1ORCID,Rengarajan Sunaina1,Solomon Benjamin D.1ORCID,Ai Teresa L.1ORCID,Shen Zeli2,Perry Justin S. A.1,Knoop Kathryn A.3,Tanoue Takeshi4,Narushima Seiko4,Honda Kenya4,Elson Charles O.5,Newberry Rodney D.3,Stappenbeck Thaddeus S.6,Kau Andrew L.7,Peterson Daniel A.8,Fox James G.2,Hsieh Chyi-Song1ORCID

Affiliation:

1. Division of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

2. Division of Comparative Medicine, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

3. Division of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

4. RIKEN Center for Integrative Medical Sciences, Tsurumi, Yokohama, Kanagawa 230-0045, Japan.

5. Division of Gastroenterology and Hepatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.

6. Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.

7. Center for Women’s Infectious Disease Research and Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

8. Eli Lilly and Co., Indianapolis, IN 46285, USA.

Abstract

Helicobacter in the intestine induce regulatory T cells during homeostasis and effector T cells during colonic inflammation.

Funder

National Institutes of Health

NIH Office of the Director

Burroughs Wellcome Fund

Crohn’s and Colitis Foundation of America

american academy of allergy, asthma and immunology foundation

National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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