Gut-resident CX3CR1 hi macrophages induce tertiary lymphoid structures and IgA response in situ

Author:

Koscsó Balázs1ORCID,Kurapati Sravya12,Rodrigues Richard R.3,Nedjic Jelena4ORCID,Gowda Kavitha5,Shin Changsik5,Soni Chetna5ORCID,Ashraf Azree Zaffran1,Purushothaman Indira6ORCID,Palisoc Maryknoll7ORCID,Xu Sulei8,Sun Haoyu8ORCID,Chodisetti Sathi Babu5ORCID,Lin Eugene1ORCID,Mack Matthias9,Kawasawa Yuka Imamura10ORCID,He Pingnian8ORCID,Rahman Ziaur S. M.5,Aifantis Iannis4ORCID,Shulzhenko Natalia11,Morgun Andrey3ORCID,Bogunovic Milena1512ORCID

Affiliation:

1. Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.

2. Biomedical Sciences PhD Program, Penn State University College of Medicine, Hershey, PA, USA.

3. College of Pharmacy, Oregon State University, Corvallis, OR, USA.

4. Department of Pathology and Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY, USA.

5. Department of Microbiology and Immunology, Penn State University College of Medicine, Hershey, PA, USA.

6. PhD Program in Anatomy at Penn State College of Medicine, Penn State University College of Medicine, Hershey, PA, USA.

7. MD/PhD Medical Scientist Training Program, Penn State University College of Medicine, Hershey, PA, USA.

8. Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, PA, USA.

9. Department of Internal Medicine/Nephrology, University Hospital Regensburg, Regensburg, Germany.

10. Department of Pharmacology and Biochemistry and Molecular Biology, Institute of Personalized Medicine, Penn State University College of Medicine, Hershey, PA, USA.

11. College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA.

12. Inflammatory Bowel Disease Center, Milton S. Hershey Medical Center, Hershey, PA, USA.

Abstract

Gut-resident CX3CR1 hi macrophages drive formation of tertiary lymphoid structures that initiate IgA responses to Salmonella infection.

Funder

NIH Office of the Director

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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