Selective Janus kinase inhibition preserves interferon-λ–mediated antiviral responses

Author:

Schnepf Daniel12ORCID,Crotta Stefania3ORCID,Thamamongood Thiprampai1245ORCID,Stanifer Megan6ORCID,Polcik Laura1,Ohnemus Annette1ORCID,Vier Juliane7,Jakob Celia1ORCID,Llorian Miriam8ORCID,Gad Hans Henrik9ORCID,Hartmann Rune9ORCID,Strobl Birgit10ORCID,Kirschnek Susanne7ORCID,Boulant Steeve11ORCID,Schwemmle Martin15ORCID,Wack Andreas3ORCID,Staeheli Peter15ORCID

Affiliation:

1. Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany.

2. Spemann Graduate School of Biology and Medicine, Albert Ludwigs University Freiburg, Freiburg, Germany.

3. Immunoregulation Laboratory, The Francis Crick Institute, London, UK.

4. Faculty of Biology, University of Freiburg, Freiburg, Germany.

5. Faculty of Medicine, University of Freiburg, Freiburg, Germany.

6. Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.

7. Faculty of Medicine, Institute of Medical Microbiology and Hygiene, Medical Center University of Freiburg, Freiburg, Germany.

8. Bioinformatics and Biostatistics, The Francis Crick Institute, London, UK.

9. Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.

10. Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria.

11. Department of Infectious Diseases, Virology, Heidelberg University, Heidelberg, Germany.

Abstract

TYK2 is required for efficient IFN-α/β signaling but dispensable for IFN-λ–mediated antiviral protection in epithelial cells.

Funder

Francis Crick Institute

Deutsche Forschungsgemeinschaft

Excellence Initiative of the German Research Foundation

Austrian Science Fund

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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