Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome-Reference-Cited by-同舟云学术

Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome

Published:2020-01-03 Issue:43 Volume:5 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Liu Yuying¹²^ORCID,Fang Yiliang¹^ORCID,Chen Xinfeng³^ORCID,Wang Zhenfeng¹^ORCID,Liang Xiaoyu¹^ORCID,Zhang Tianzhen¹^ORCID,Liu Mengyu¹^ORCID,Zhou Nannan¹^ORCID,Lv Jiadi¹^ORCID,Tang Ke⁴^ORCID,Xie Jing¹^ORCID,Gao Yunfeng¹^ORCID,Cheng Feiran¹^ORCID,Zhou Yabo¹^ORCID,Zhang Zhen³^ORCID,Hu Yu⁵^ORCID,Zhang Xiaohui⁶^ORCID,Gao Quanli⁷^ORCID,Zhang Yi³^ORCID,Huang Bo¹²⁴^ORCID

Affiliation:

1. Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College, Beijing 100005, China.

2. Clinical Immunology Center, CAMS, Beijing 100005, China.

3. Biotherapy Center and Cancer Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China.

4. Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

5. Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

6. Peking University People’s Hospital, Peking University Institute of Hematology, Beijing 100044, China.

7. Department of Immunology, Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, Henan 450008, China.

Abstract

GSDME-mediated target cell pyroptosis by CAR T cells activates macrophages to release proinflammatory cytokines for CRS.

Funder

National Natural Science Foundation of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference45 articles.

1. Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

2. Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

3. Therapeutic T cell engineering

4. Toxicity and management in CAR T-cell therapy

5. Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia

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