Potent and broad HIV-neutralizing antibodies in memory B cells and plasma

Author:

Williams LaTonya D.1,Ofek Gilad2,Schätzle Sebastian3,McDaniel Jonathan R.3,Lu Xiaozhi1,Nicely Nathan I.1,Wu Liming2,Lougheed Caleb S.2,Bradley Todd14,Louder Mark K.5,McKee Krisha5,Bailer Robert T.5,O’Dell Sijy5,Georgiev Ivelin S.6,Seaman Michael S.7,Parks Robert J.1,Marshall Dawn J.1,Anasti Kara1,Yang Guang1,Nie Xiaoyan1,Tumba Nancy L.89,Wiehe Kevin14,Wagh Kshitij10,Korber Bette10,Kepler Thomas B.11,Munir Alam S.1412,Morris Lynn89,Kamanga Gift13,Cohen Myron S.14,Bonsignori Mattia14,Xia Shi-Mao1,Montefiori David C.115,Kelsoe Garnett116,Gao Feng14,Mascola John R.5,Moody M. Anthony11617,Saunders Kevin O.115,Liao Hua-Xin14,Tomaras Georgia D.1151618,Georgiou George319,Haynes Barton F.1416

Affiliation:

1. Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

2. Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD 20850, USA.

3. Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA.

4. Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

5. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.

6. Vanderbilt Vaccine Center and Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

7. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

8. Centre for HIV and STIs, National Institute for Communicable Diseases, Johannesburg 2131, South Africa.

9. Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Congella 4013, South Africa.

10. Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

11. Departments of Microbiology and Mathematics & Statistics, Boston University School of Medicine, Boston, MA 02118, USA.

12. Department of Pathology, Duke University School of Medicine, Durham, NC 27710, USA.

13. University of North Carolina Project-Malawi, Kamuzu Central Hospital, Lilongwe, Malawi.

14. Departments of Medicine, Epidemiology, and Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA.

15. Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.

16. Department of Immunology, Duke University School of Medicine, Durham, NC 27710, USA.

17. Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA.

18. Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.

19. Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.

Abstract

Plasma is a source of broadly neutralizing antibodies for recombinant antibodies with enhanced potency and breadth.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3