Citrullination of NF-κB p65 promotes its nuclear localization and TLR-induced expression of IL-1β and TNFα-Reference-Cited by-同舟云学术

Citrullination of NF-κB p65 promotes its nuclear localization and TLR-induced expression of IL-1β and TNFα

Published:2017-06-09 Issue:12 Volume:2 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Sun Bo¹²^ORCID,Dwivedi Nishant¹²^ORCID,Bechtel Tyler J.³^ORCID,Paulsen Janet L.⁴,Muth Aaron⁴^ORCID,Bawadekar Mandar⁵^ORCID,Li Gang¹²,Thompson Paul R.⁴^ORCID,Shelef Miriam A.⁶,Schiffer Celia A.⁴^ORCID,Weerapana Eranthie³^ORCID,Ho I-Cheng¹²^ORCID

Affiliation:

1. Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.

2. Harvard Medical School, Boston, MA 02115, USA.

3. Department of Chemistry, Boston College, Chestnut Hill, MA 02467, USA.

4. Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

5. Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.

6. Department of Medicine, University of Wisconsin-Madison and William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA.

Abstract

Heightened citrullination promotes the expression of inflammatory cytokines in rheumatoid arthritis.

Funder

NIH Office of the Director

Rheumatology Research Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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5. Dysregulation of PAD4-mediated citrullination of nuclear GSK3 activates TGF- signaling and induces epithelial-to-mesenchymal transition in breast cancer cells

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