T cell engagement of cross-presenting microglia protects the brain from a nasal virus infection

Author:

Moseman E. Ashley12ORCID,Blanchard Alexa C.1ORCID,Nayak Debasis3ORCID,McGavern Dorian B.1ORCID

Affiliation:

1. Viral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

2. Department of Immunology, Duke University School of Medicine, Durham, NC, USA.

3. Discipline of Bioscience and Biomedical Engineering, Indian Institute of Technology Indore, MP, India.

Abstract

Microglia protect the brain from an intranasal VSV infection by cross-presenting neuronal antigen to antiviral CD8 + T cells.

Funder

National Institute of Neurological Disorders and Stroke

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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