Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1

Author:

Howson Lauren J.1ORCID,Awad Wael12ORCID,von Borstel Anouk1ORCID,Lim Hui Jing3ORCID,McWilliam Hamish E. G.34ORCID,Sandoval-Romero Maria L.1ORCID,Majumdar Shamik5,Hamzeh Abdul Rezzak67,Andrews Thomas D.67ORCID,McDermott David H.5ORCID,Murphy Philip M.5ORCID,Le Nours Jérôme12ORCID,Mak Jeffrey Y. W.89ORCID,Liu Ligong89ORCID,Fairlie David P.89ORCID,McCluskey James3ORCID,Villadangos Jose A.34ORCID,Cook Matthew C.67,Turner Stephen J.10ORCID,Davey Martin S.1ORCID,Ojaimi Samar111213ORCID,Rossjohn Jamie1214ORCID

Affiliation:

1. Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

2. Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.

3. Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia.

4. Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia.

5. Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.

6. Centre for Personalised Immunology, John Curtin School of Medical Research, Australian National University, Acton, Australian Capital Territory, Australia.

7. Department of Immunology, Canberra Hospital, Canberra, Australian Capital Territory, Australia.

8. Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.

9. ARC Centre of Excellence in Advanced Molecular Imaging, University of Queensland, Brisbane, Queensland, Australia.

10. Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

11. Department of Infectious Diseases, Monash Health, Clayton, Victoria, Australia.

12. Centre for Inflammatory Diseases, Monash University, Clayton, Victoria, Australia.

13. Department of Allergy and Immunology, Monash Health, Clayton, Victoria, Australia.

14. Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK.

Abstract

A rare human allele renders MR1 unable to present microbially derived antigen, resulting in a selective loss of MAIT cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3