Pathogen-induced tissue-resident memory T H 17 (T RM 17) cells amplify autoimmune kidney disease

Author:

Krebs Christian F.12ORCID,Reimers Daniel3ORCID,Zhao Yu4ORCID,Paust Hans-Joachim1,Bartsch Patricia1ORCID,Nuñez Sarah5ORCID,Rosemblatt Mariana V.6ORCID,Hellmig Malte1,Kilian Christoph1ORCID,Borchers Alina1,Enk Leon U. B.1ORCID,Zinke Michael1ORCID,Becker Martina7ORCID,Schmid Joanna3,Klinge Stefanie3ORCID,Wong Milagros N.7,Puelles Victor G.78ORCID,Schmidt Constantin3ORCID,Bertram Tabea3ORCID,Stumpf Natascha9ORCID,Hoxha Elion7,Meyer-Schwesinger Catherine10,Lindenmeyer Maja T.7,Cohen Clemens D.711ORCID,Rink Michael12,Kurts Christian9ORCID,Franzenburg Sören13ORCID,Koch-Nolte Friedrich23ORCID,Turner Jan-Eric27,Riedel Jan-Hendrik1ORCID,Huber Samuel214ORCID,Gagliani Nicola21415,Huber Tobias B.27ORCID,Wiech Thorsten6ORCID,Rohde Holger16,Bono Maria Rosa17ORCID,Bonn Stefan241819ORCID,Panzer Ulf12,Mittrücker Hans-Willi23ORCID

Affiliation:

1. III. Department of Medicine, Division of Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

2. Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

3. Institute for Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

4. Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

5. Fundacion Ciencia Vida, Santiago, Chile.

6. Faculty of Medicine and Science, Universidad San Sebastian, Santiago, Chile.

7. III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

8. Department of Nephrology, Monash Health, and Center for Inflammatory Diseases, Monash University, Melbourne, VIC, Australia.

9. Institutes of Molecular Medicine and Experimental Immunology (IMMEI), Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany.

10. Institute for Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

11. Nephrological Center, Medical Clinic and Policlinic IV, University of Munich, Munich, Germany.

12. Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

13. Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.

14. I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

15. Immunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University Hospital, 17176 Stockholm, Sweden.

16. Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

17. Department of Biology, Faculty of Sciences, Universidad de Chile, Santiago, Chile.

18. German Center for Neurodegenerative Diseases, Tübingen, Germany.

19. Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Abstract

CD4 + T RM 17 cells become activated by inflammatory cytokines to produce IL-17A and thereby promote autoimmunity.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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