Targeted deletion of PD-1 in myeloid cells induces antitumor immunity-Reference-Cited by-同舟云学术

Targeted deletion of PD-1 in myeloid cells induces antitumor immunity

Published:2020-01-03 Issue:43 Volume:5 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Strauss Laura¹²³^ORCID,Mahmoud Mohamed A. A.¹²³,Weaver Jessica D.¹²³^ORCID,Tijaro-Ovalle Natalia M.¹²³^ORCID,Christofides Anthos¹²³^ORCID,Wang Qi¹²³,Pal Rinku¹²³^ORCID,Yuan Min³^ORCID,Asara John³^ORCID,Patsoukis Nikolaos¹²³^ORCID,Boussiotis Vassiliki A.¹²³^ORCID

Affiliation:

1. Division of Hematology-Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

2. Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

3. Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Abstract

PD-1 ablation regulates metabolism-driven lineage fate commitment of myeloid progenitors and differentiation of effector myeloid cells (see the related Focus by Rudd ).

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference71 articles.

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3. Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer

4. Attenuation of the programmed cell death-1 pathway increases the M1 polarization of macrophages induced by zymosan

5. PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis

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