The insulin response integrates increased TGF-β signaling through Akt-induced enhancement of cell surface delivery of TGF-β receptors-Reference-Cited by-同舟云学术

The insulin response integrates increased TGF-β signaling through Akt-induced enhancement of cell surface delivery of TGF-β receptors

Published:2015-09-29 Issue:396 Volume:8 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Budi Erine H.¹,Muthusamy Baby-Periyanayaki¹,Derynck Rik¹

Affiliation:

1. Departments of Cell and Tissue Biology, and Anatomy, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California at San Francisco, San Francisco, CA 94143–0669, USA.

Abstract

Insulin enhances the response to TGF-β, a cytokine that promotes fibrosis.

Funder

NIH

UCSF's Program in Biomedical Breakthrough Research (PBBR)

Juvenile Diabetes Research Fund (JDRF)

PBBR Fellowship

NIH T32

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference106 articles.

1. TGFβ in Cancer

2. TGFβ signalling: a complex web in cancer progression

3. Epithelial-Mesenchymal Interactions in Pulmonary Fibrosis

4. TGFβ and matrix-regulated epithelial to mesenchymal transition

5. TGF‐β signaling and the fibrotic response

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