An Adenosine-Mediated Signaling Pathway Suppresses Prenylation of the GTPase Rap1B and Promotes Cell Scattering-Reference-Cited by-同舟云学术

An Adenosine-Mediated Signaling Pathway Suppresses Prenylation of the GTPase Rap1B and Promotes Cell Scattering

Published:2013-05-28 Issue:277 Volume:6 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Ntantie Elizabeth¹,Gonyo Patrick¹,Lorimer Ellen L.¹,Hauser Andrew D.¹,Schuld Nathan¹,McAllister Donna²,Kalyanaraman Balaraman²,Dwinell Michael B.³,Auchampach John A.¹,Williams Carol L.¹

Affiliation:

1. Department of Pharmacology and Toxicology, Cancer Center, and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

2. Department of Biophysics and Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

3. Department of Microbiology and Molecular Genetics and Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Abstract

Inhibition of adenosine receptors could reduce metastasis by enhancing prenylation-dependent signaling that promotes cell-cell adhesion.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference50 articles.

1. Rap1 GTPase Regulation of Adherens Junction Positioning and Cell Adhesion

2. Rap1 Regulates E-cadherin-mediated Cell-Cell Adhesion

3. DOCK4, a GTPase Activator, Is Disrupted during Tumorigenesis

4. Rap1: a key regulator in cell-cell junction formation

5. Control of cell adhesion dynamics by Rap1 signaling

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