Dynamic variability in SHP-1 abundance determines natural killer cell responsiveness

Author:

Wu Zeguang12ORCID,Park Soo12,Lau Colleen M.2ORCID,Zhong Yi2,Sheppard Sam2,Sun Joseph C.234ORCID,Das Jayajit5678ORCID,Altan-Bonnet Grégoire9ORCID,Hsu Katharine C.1241011ORCID

Affiliation:

1. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

2. Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

3. Department of Immunology and Microbial Pathogenesis, Weill Cornell Medical College, New York, NY 10065, USA.

4. Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

5. Battelle Center for Mathematical Medicine, Research Institute at the Nationwide Children’s Hospital, Columbus, OH 43205, USA.

6. Department of Pediatrics, Pelotonia Institute of ImmunoOncology, Wexner College of Medicine, Ohio State University, Columbus, OH 43210, USA.

7. Department of Biomedical Informatics, Ohio State University, Columbus, OH 43210, USA.

8. Biophysics Graduate Program, Ohio State University, Columbus, OH 43210, USA.

9. Immunodynamics Group, Cancer and Inflammation Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20814, USA.

10. Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.

11. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Abstract

The responsiveness of mouse and human natural killer cells is inversely correlated with the abundance of the phosphatase SHP-1.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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