IL-2Rβ abundance differentially tunes IL-2 signaling dynamics in CD4 + and CD8 + T cells-Reference-Cited by-同舟云学术

IL-2Rβ abundance differentially tunes IL-2 signaling dynamics in CD4 + and CD8 + T cells

Published:2017-12-19 Issue:510 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Smith Geoffrey A.¹²^ORCID,Taunton Jack¹,Weiss Arthur²³^ORCID

Affiliation:

1. Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA.

2. Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, Division of Rheumatology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

3. Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.

Abstract

Receptor abundance determines the temporal signaling pattern and proliferative response in T cells stimulated with interleukin-2.

Funder

Howard Hughes Medical Institute

National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference36 articles.

1. New insights into the regulation of T cells by γc family cytokines

2. Critical Role of STAT5 Transcription Factor Tetramerization for Cytokine Responses and Normal Immune Function

3. Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition

4. The Interleukin-2 T-Cell System: A New Cell Growth Model

5. Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling

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