HCMV-Encoded Chemokine Receptor US28 Mediates Proliferative Signaling Through the IL-6

HCMV-Encoded Chemokine Receptor US28 Mediates Proliferative Signaling Through the IL-6–STAT3 Axis

Published:2010-08-03 Issue:133 Volume:3 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Slinger Erik¹,Maussang David¹,Schreiber Andreas¹,Siderius Marco¹,Rahbar Afsar²,Fraile-Ramos Alberto³⁴,Lira Sergio A.⁵,Söderberg-Nauclér Cecilia²,Smit Martine J.¹

Affiliation:

1. Leiden/Amsterdam Center for Drug Research, Division of Medicinal Chemistry, Faculty of Sciences, VU University Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, the Netherlands.

2. Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital Solna and Karolinska Institutet, 171 76 Stockholm, Sweden.

3. Department of Molecular and Cell Biology, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Campus Universidad Autonoma de Madrid, 28006 Madrid, Spain.

4. MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.

5. Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA.

Abstract

A viral G protein–coupled receptor may initiate a positive feedback loop to promote tumor proliferation and vascularization.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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