Phosphoproteomic Analysis Reveals Interconnected System-Wide Responses to Perturbations of Kinases and Phosphatases in Yeast

Author:

Bodenmiller Bernd12,Wanka Stefanie23,Kraft Claudine4,Urban Jörg5,Campbell David6,Pedrioli Patrick G.4,Gerrits Bertran7,Picotti Paola1,Lam Henry8,Vitek Olga9,Brusniak Mi-Youn6,Roschitzki Bernd7,Zhang Chao10,Shokat Kevan M.10,Schlapbach Ralph7,Colman-Lerner Alejandro11,Nolan Garry P.12,Nesvizhskii Alexey I.13,Peter Matthias4,Loewith Robbie5,von Mering Christian3,Aebersold Ruedi1614

Affiliation:

1. Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland.

2. Zurich PhD Program in Molecular Life Sciences, 8057 Zurich, Switzerland.

3. Institute of Molecular Life Sciences and Swiss Institute of Bioinformatics, University of Zurich, 8057 Zurich, Switzerland.

4. Institute of Biochemistry, ETH Zurich, 8093 Zurich, Switzerland.

5. Department of Molecular Biology, University of Geneva, Geneva 1211, Switzerland.

6. Institute for Systems Biology, Seattle, WA 98103, USA.

7. Functional Genomics Center Zurich, University Zurich and ETH Zurich, 8057 Zurich, Switzerland.

8. Department of Chemical and Biomolecular Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong.

9. Departments of Statistics and Computer Science, Purdue University, West Lafayette, IN 47107, USA.

10. Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158–2280, USA.

11. Facultad de Ciencias Exactas y Naturales, University of Buenos Aires, C1428EHA Buenos Aires, Argentina.

12. Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

13. Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.

14. Faculty of Science, University of Zurich, 8057 Zurich, Switzerland.

Abstract

A system-wide analysis of protein phosphorylation in yeast reveals robustness in the network of kinases and phosphatases.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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