The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b

Author:

Zhou Wu1ORCID,Ye Xiao-lei2,Xu Jun1,Cao Ming-Guo1,Fang Zheng-Yu1,Li Ling-Yun3,Guan Guang-Hui2,Liu Qiong2,Qian Yue-Hui4,Xie Dong5ORCID

Affiliation:

1. Department of Medicine, College of Medicine and Health, Lishui University, Zhejiang 323000, China.

2. Division of Drugs and Pharmacology, Ningbo Institute of Medical Sciences, Zhejiang 315020, China.

3. Laboratory of Medicine, People’s Hospital of Lishui City, Lishui 323000, China.

4. Department of Laboratory Animal Science, Tianjin Medical University, Tianjin 300007, China.

5. Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Abstract

A long noncoding RNA selectively sponges microRNAs to enable epithelial-mesenchymal plasticity in metastasizing breast cancer cells.

Funder

National Natural Science Foundation of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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