Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodeling

Author:

Williams Steven P.123ORCID,Odell Adam F.14ORCID,Karnezis Tara14,Farnsworth Rae H.14ORCID,Gould Cathryn M.5,Li Jason46,Paquet-Fifield Sophie14ORCID,Harris Nicole C.123ORCID,Walter Anne7,Gregory Julia L.7ORCID,Lamont Sara F.18,Liu Ruofei14ORCID,Takano Elena A.19ORCID,Nowell Cameron J.310ORCID,Bower Neil I.11,Resnick Daniel13ORCID,Smyth Gordon K.1213ORCID,Coultas Leigh1415,Hogan Benjamin M.11,Fox Stephen B.19ORCID,Mueller Scott N.7ORCID,Simpson Kaylene J.45,Achen Marc G.1234,Stacker Steven A.1234ORCID

Affiliation:

1. Tumour Angiogenesis and Microenvironment Program, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.

2. Department of Surgery, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria 3010, Australia.

3. Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia.

4. Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3010, Australia.

5. Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.

6. Bioinformatics Core, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.

7. Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria 3000, Australia.

8. Department of Biochemistry and Genetics, La Trobe Institute for Molecular Sciences, La Trobe University, Bundoora, Victoria 3086, Australia.

9. Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.

10. Centre for Dynamic Imaging, Systems Biology and Personalised Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.

11. Division of Genomics of Development and Disease, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.

12. School of Mathematics and Statistics, University of Melbourne, Parkville, Victoria 3010, Australia.

13. Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.

14. Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia.

15. Development and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.

Abstract

The signaling proteins and pathways involved in lymphatic endothelial cell migration are identified through a functional screen.

Funder

National Health and Medical Research Council

National Breast Cancer Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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