Selective Effects of PD-1 on Akt and Ras Pathways Regulate Molecular Components of the Cell Cycle and Inhibit T Cell Proliferation-Reference-Cited by-同舟云学术

Selective Effects of PD-1 on Akt and Ras Pathways Regulate Molecular Components of the Cell Cycle and Inhibit T Cell Proliferation

Published:2012-06-26 Issue:230 Volume:5 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Patsoukis Nikolaos¹,Brown Julia¹,Petkova Victoria¹,Liu Fang²,Li Lequn¹,Boussiotis Vassiliki A.¹

Affiliation:

1. Department of Hematology-Oncology and Cancer Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

2. Center for Advanced Biotechnology and Medicine and Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, Piscataway, NJ 08854, USA.

Abstract

The inhibitory receptor PD-1 blocks T cell proliferation by preventing cells from leaving the G 1 phase of the cell cycle.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference74 articles.

1. The enemy within: keeping self-reactive T cells at bay in the periphery

2. Physiologic regulation of central and peripheral T cell tolerance: lessons for therapeutic applications

3. The PD-1 pathway in tolerance and autoimmunity

4. PD-1 Regulates Self-Reactive CD8+ T Cell Responses to Antigen in Lymph Nodes and Tissues

5. Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4

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