TMEM16F mediates bystander TCR-CD3 membrane dissociation at the immunological synapse and potentiates T cell activation-Reference-Cited by-同舟云学术

TMEM16F mediates bystander TCR-CD3 membrane dissociation at the immunological synapse and potentiates T cell activation

Published:2021-03-23 Issue:675 Volume:14 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Connolly Audrey¹²^ORCID,Panes Rébecca¹²^ORCID,Tual Margaux¹²,Lafortune Raphaël²,Bellemare-Pelletier Angélique¹^ORCID,Gagnon Etienne¹²^ORCID

Affiliation:

1. Institut de Recherche en Immunologie et Cancérologie, 2950 Chemin de la Polytechnique, Montréal, Québec H3T1J4, Canada.

2. Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université de Montréal, 2900 Édouard-Montpetit, Montréal, Québec H3T1J4, Canada.

Abstract

The scramblase TMEM16F flips the distribution of phosphatidylserine in the T cell plasma membrane to activate bystander TCRs.

Funder

Canadian Institutes of Health Research

Natural Sciences and Engineering Research Council of Canada

Canada Foundation for Innovation

NSERC

CIHR-IRSC

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference58 articles.

1. TCR Signaling: Mechanisms of Initiation and Propagation

2. The T cell receptor: the α and β chains define idiotype, and antigen and MHC specificity

3. The Serial Engagement Model 17 Years After: From TCR Triggering to Immunotherapy

4. Do T cells need endogenous peptides for activation?

5. Serial triggering of many T-cell receptors by a few peptide–MHC complexes

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