Old Dance with a New Partner: EGF Receptor as the Phenobarbital Receptor Mediating Cyp2B Expression

Author:

Meyer Sharon A.1,Jirtle Randy L.2

Affiliation:

1. Department of Toxicology, College of Pharmacy, University of Louisiana, Monroe, LA 71201, USA.

2. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI 53706, USA.

Abstract

The direct interaction of phenobarbital with the epidermal growth factor receptor reveals a new network interface in nuclear receptor signaling.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference11 articles.

1. RACK1, A multifaceted scaffolding protein: Structure and function

2. L. E. Limbird Cell Surface Receptors: A Short Course on Theory and Methods (Springer New York 2005) pp. 65–106.

3. The Nuclear Orphan Receptor CAR-Retinoid X Receptor Heterodimer Activates the Phenobarbital-Responsive Enhancer Module of the CYP2B Gene

4. An okadaic acid-sensitive pathway involved in the phenobarbital-mediated induction of CYP2B gene expression in primary rat hepatocyte cultures;Sidhu J. S.;J. Pharmacol. Exp. Ther.,1997

5. Dephosphorylation of Threonine 38 Is Required for Nuclear Translocation and Activation of Human Xenobiotic Receptor CAR (NR1I3)

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