Oxygen-dependent changes in binding partners and post-translational modifications regulate the abundance and activity of HIF-1α/2α-Reference-Cited by-同舟云学术

Oxygen-dependent changes in binding partners and post-translational modifications regulate the abundance and activity of HIF-1α/2α

Published:2021-07-20 Issue:692 Volume:14 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Daly Leonard A.¹²^ORCID,Brownridge Philip J.²^ORCID,Batie Michael³^ORCID,Rocha Sonia³^ORCID,Sée Violaine³⁴^ORCID,Eyers Claire E.¹²^ORCID

Affiliation:

1. Department of Biochemistry and System Biology, Institute of Systems, Molecular, and Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK.

2. Centre for Proteome Research, University of Liverpool, Liverpool L69 7ZB, UK.

3. Department of Molecular Physiology and Cell Signaling, Institute of Systems, Molecular, and Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK.

4. Centre for Cell Imaging, University of Liverpool, Liverpool L69 7ZB, UK.

Abstract

The oxygen-dependent regulation of hypoxia-inducible factors is more complex than previously appreciated.

Funder

Medical Research Council

Biotechnology and Biological Sciences Research Council

Medical Research Council Canada

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference72 articles.