Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome-Reference-Cited by-同舟云学术

Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome

Published:2016-06-07 Issue:431 Volume:9 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Kashima Risa¹,Roy Sougata¹,Ascano Manuel²,Martinez-Cerdeno Veronica³⁴,Ariza-Torres Jeanelle³,Kim Sunghwan¹,Louie Justin¹,Lu Yao¹,Leyton Patricio⁵,Bloch Kenneth D.⁵,Kornberg Thomas B.¹,Hagerman Paul J.⁶,Hagerman Randi⁴,Lagna Giorgio¹,Hata Akiko¹

Affiliation:

1. Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.

2. Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA.

3. Institute for Pediatric Regenerative Medicine, Department of Pathology, University of California, Davis, Davis, CA 95817, USA.

4. MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California, Davis, Davis, CA 95817, USA.

5. Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA.

6. Department of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA 95817, USA.

Abstract

Blocking a BMP signaling pathway may ameliorate neurological defects in patients with fragile X syndrome.

Funder

Foundation LeDucq

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference77 articles.

1. Advances in clinical and molecular understanding of the FMR1 premutation and fragile X-associated tremor/ataxia syndrome

2. Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us

3. Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics

4. Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

5. Mapping of DNA Instability at the Fragile X to a Trinucleotide Repeat Sequence P(CCG) n

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