R-Ras2 is required for germinal center formation to aid B cells during energetically demanding processes-Reference-Cited by-同舟云学术

R-Ras2 is required for germinal center formation to aid B cells during energetically demanding processes

Published:2018-05-29 Issue:532 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Mendoza Pilar¹^ORCID,Martínez-Martín Nuria¹^ORCID,Bovolenta Elena R.¹,Reyes-Garau Diana¹^ORCID,Hernansanz-Agustín Pablo²,Delgado Pilar¹^ORCID,Diaz-Muñoz Manuel D.³^ORCID,Oeste Clara L.¹^ORCID,Fernández-Pisonero Isabel⁴^ORCID,Castellano Ester⁴,Martínez-Ruiz Antonio²⁵^ORCID,Alonso-Lopez Diego⁴^ORCID,Santos Eugenio⁴^ORCID,Bustelo Xosé R.⁴^ORCID,Kurosaki Tomohiro⁶^ORCID,Alarcón Balbino¹^ORCID

Affiliation:

1. Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.

2. Servicio de Inmunología, Hospital de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain.

3. INSERM UMR1043/CNRS UMR5282, Centre Hospitalier Universitaire (CHU) Purpan, BP3028, 31024 Toulouse, France.

4. Centro de Investigación del Cáncer, Instituto de Biología Molecular y Celular del Cancer, and Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Consejo Superior de Investigaciones Científicas (CSIC)–University of Salamanca, Campus Unamuno s/n, 37007 Salamanca, Spain.

5. Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), 28006 Madrid, Spain.

6. Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Tsurumi-ku, Kanagawa 230-0045, and Laboratory of Lymphocyte Differentiation, World Premier Institute (WPI) Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.

Abstract

Metabolic reprogramming of germinal center B cells requires the activity of R-Ras2.

Funder

Fundación Ramón Areces

Worldwide Cancer Research

Spanish Ministry of Economy and Competitiveness

Consejeri-a de Educacion, Junta de Castilla y Leon

Spanish Association against Cancer

Consejeria de Sanidad, Junta de Castilla y Leon

Publisher

American Association for the Advancement of Science (AAAS)

Subject