Antagonism of EGFR and HER3 Enhances the Response to Inhibitors of the PI3K-Akt Pathway in Triple-Negative Breast Cancer

Author:

Tao Jessica J.1,Castel Pau2,Radosevic-Robin Nina34,Elkabets Moshe2,Auricchio Neil1,Aceto Nicola1,Weitsman Gregory5,Barber Paul67,Vojnovic Borivoj68,Ellis Haley2,Morse Natasha2,Viola-Villegas Nerissa Therese9,Bosch Ana2,Juric Dejan1,Hazra Saswati10,Singh Sharat10,Kim Phillip10,Bergamaschi Anna11,Maheswaran Shyamala1,Ng Tony512,Penault-Llorca Frédérique34,Lewis Jason S.9,Carey Lisa A.13,Perou Charles M.14,Baselga José2,Scaltriti Maurizio2

Affiliation:

1. Massachusetts General Hospital Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA.

2. Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA.

3. Department of Biopathology, Centre Jean Perrin, 58 rue Montalembert, 63011 Clermont-Ferrand, France.

4. ERTICA EA4677, University of Auvergne, 63000 Clermont-Ferrand, France.

5. Richard Dimbleby Department of Cancer Research, Randall Division of Cell & Molecular Biophysics and Division of Cancer Studies, King’s College London, London SE1 1UL, UK.

6. Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.

7. Institute for Mathematical and Molecular Biomedicine, King’s College London, London SE1 1UL, UK.

8. Randall Division of Cell & Molecular Biophysics, King’s College London, London SE1 1UL, UK.

9. Department of Radiology and Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

10. Prometheus Therapeutics & Diagnostics, 9410 Carroll Park Drive, San Diego, CA 92121, USA.

11. Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, IL 61801, USA.

12. UCL Cancer Institute, Paul O’Gorman Building, University College London, London WC1E 6DD, UK.

13. Department of Medicine, University of North Carolina at Chapel Hill, 170 Manning Drive, Chapel Hill, NC 27599, USA.

14. Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Abstract

Predictions regarding drug resistance mechanisms and treatment strategies in triple-negative breast cancer are confirmed in tumors from patients.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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