Regulation of the error-prone DNA polymerase Polκ by oncogenic signaling and its contribution to drug resistance-Reference-Cited by-同舟云学术

Regulation of the error-prone DNA polymerase Polκ by oncogenic signaling and its contribution to drug resistance

Published:2020-04-28 Issue:629 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Temprine Kelsey¹²^ORCID,Campbell Nathaniel R.¹³^ORCID,Huang Richard¹^ORCID,Langdon Erin M.⁴^ORCID,Simon-Vermot Theresa¹^ORCID,Mehta Krisha⁵,Clapp Averill⁶^ORCID,Chipman Mollie¹²^ORCID,White Richard M¹^ORCID

Affiliation:

1. Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

2. Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

3. Tri-Institutional M.D./Ph.D. Program, Weill Cornell Medical College, New York, NY 10065, USA.

4. University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.

5. Division of General Internal Medicine, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.

6. University of Chicago, Chicago, IL 60637, USA.

Abstract

DNA polymerase κ mediates drug resistance in tumor cells through a mechanism that could be independent of mutagenesis.

Funder

National Institutes of Health

Melanoma Research Alliance

Harry J. Lloyd Charitable Trust

Pershing Square Foundation

Alan and Sandra Gerry Metastasis Research Initiative MSKCC

Consano

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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1. Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

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