RNF4-Dependent Hybrid SUMO-Ubiquitin Chains Are Signals for RAP80 and Thereby Mediate the Recruitment of BRCA1 to Sites of DNA Damage-Reference-Cited by-同舟云学术

RNF4-Dependent Hybrid SUMO-Ubiquitin Chains Are Signals for RAP80 and Thereby Mediate the Recruitment of BRCA1 to Sites of DNA Damage

Published:2012-12-04 Issue:253 Volume:5 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Guzzo Catherine M.¹,Berndsen Christopher E.²,Zhu Jianmei¹,Gupta Vibhor³,Datta Ajit²,Greenberg Roger A.³,Wolberger Cynthia²,Matunis Michael J.¹

Affiliation:

1. Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.

2. Department of Biophysics and Biophysical Chemistry and the Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

3. Department of Cancer Biology and Department of Pathology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

DNA repair proteins find sites of damage marked by hybrid SUMO-ubiquitin chains.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference40 articles.

1. The DNA Damage Response: Making It Safe to Play with Knives

2. ATM-Dependent and -Independent Dynamics of the Nuclear Phosphoproteome After DNA Damage

3. MRN and the race to the break

4. The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks

5. Principles of ubiquitin and SUMO modifications in DNA repair

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