PERK mediates the IRES-dependent translational activation of mRNAs encoding angiogenic growth factors after ischemic stress-Reference-Cited by-同舟云学术

PERK mediates the IRES-dependent translational activation of mRNAs encoding angiogenic growth factors after ischemic stress

Published:2016-05-03 Issue:426 Volume:9 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Philippe Céline¹²,Dubrac Alexandre¹²,Quelen Cathy¹²,Desquesnes Aurore³,Van Den Berghe Loic¹²⁴,Ségura Christèle¹²⁴,Filleron Thomas⁵,Pyronnet Stéphane¹²⁶,Prats Hervé¹²,Brousset Pierre¹²⁶⁷,Touriol Christian¹²

Affiliation:

1. INSERM, UMR 1037, CRCT (Cancer Research Center of Toulouse), F-31037 Toulouse, France.

2. Université Toulouse III Paul Sabatier, F-31000 Toulouse, France.

3. INSERM US006, CREFRE (Centre régional d’exploration fonctionnelle et de ressources expérimentales), F-31000 Toulouse, France.

4. Vectorology Platform, CRCT Technological Pole, F-31037 Toulouse, France.

5. Clinical Trial Office, Department of Statistics, IUCT (Institut Universitaire du Cancer de Toulouse)–Oncopole, F-31100 Toulouse, France.

6. Laboratoire d’Excellence Toulouse Cancer (TOUCAN), F-31037 Toulouse, France.

7. Department of Pathology, IUCT-Oncopole, F-31100 Toulouse, France.

Abstract

PERK may promote blood vessel growth in oxygen-deprived muscles by ensuring the production of angiogenic factors.

Funder

INSERM

Institut National du Cancer (INCa)

Labex TOUCAN (Laboratoire d'Excellence Toulouse Cancer)

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference41 articles.

1. Angiogenesis in life, disease and medicine

2. Generation of protein isoform diversity by alternative initiation of translation at non-AUG codons

3. Translational Induction of VEGF Internal Ribosome Entry Site Elements During the Early Response to Ischemic Stress

4. FGF2 Translationally Induced by Hypoxia Is Involved in Negative and Positive Feedback Loops with HIF-1α

5. Translational Regulation of Gene Expression during Conditions of Cell Stress

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