γ-Secretase Limits the Inflammatory Response Through the Processing of LRP1-Reference-Cited by-同舟云学术

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γ-Secretase Limits the Inflammatory Response Through the Processing of LRP1

Published:2008-11-25 Issue:47 Volume:1 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Zurhove Kai¹²,Nakajima Chikako¹²,Herz Joachim²³,Bock Hans H.¹²,May Petra¹²

Affiliation:

1. Department of Medicine II, University Hospital and University of Freiburg, 79106 Freiburg, Germany.

2. Centre of Neurosciences, University Hospital and University of Freiburg, 79104 Freiburg, Germany.

3. Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Abstract

Cleavage of the intracellular domain of the lipoprotein receptor LRP1 allows it to transcriptionally inhibit inflammatory responses.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference55 articles.

1. Presenilin diversifies its portfolio

2. Notch Signaling Pathway

3. γ-Secretase Cleavage and Nuclear Localization of ErbB-4 Receptor Tyrosine Kinase

4. Presenilin-Dependent ErbB4 Nuclear Signaling Regulates the Timing of Astrogenesis in the Developing Brain

5. LRP: a multifunctional scavenger and signaling receptor

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1. Novel insights into the multifaceted and tissue-specific roles of the endocytic receptor LRP1;Journal of Biological Chemistry;2024-08

2. The human and mouse dendritic cell receptor DCIR binds to LRP1 N-glycans containing terminal galactoses, including the α-Gal antigen;2024-05-21

3. LRP1 facilitates hepatic glycogenesis by improving the insulin signaling pathway in HFD‐fed mice;Animal Models and Experimental Medicine;2024-04-03

4. Sestrin2 maintains hepatic immune homeostasis and redox balance partially via inhibiting RIPK3-mediated necroptosis in metabolic dysfunction-associated steatohepatitis;Molecular Metabolism;2024-02

5. The γ-secretase substrate proteome and its role in cell signaling regulation;Molecular Cell;2023-11

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