Constitutive expression of progesterone receptor isoforms promotes the development of hormone-dependent ovarian neoplasms

Author:

Wetendorf Margeaux123ORCID,Li Rong1ORCID,Wu San-Pin1ORCID,Liu Jian1ORCID,Creighton Chad J.4ORCID,Wang Tianyuan5ORCID,Janardhan Kyathanahalli S.6ORCID,Willson Cynthia J.6ORCID,Lanz Rainer B.3,Murphy Bruce D.7ORCID,Lydon John P.3,DeMayo Francesco J.1ORCID

Affiliation:

1. Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.

2. Integrative Molecular and Biomedical Sciences Graduate Program, Baylor College of Medicine, Houston, TX, USA.

3. Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX, USA.

4. Department of Medicine and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.

5. Integrative Bioinformatics, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.

6. Integrated Laboratory Systems, Research Triangle Park, NC, USA.

7. Centre de recherche en reproduction et fertilité, University of Montreal, St-Hyacinthe, QC, Canada.

Abstract

Altering the relative abundance of progesterone receptor isoforms drives ovarian neoplasia in mice.

Funder

National Cancer Institute

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of Environmental Health Sciences

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Canadian Institutes of Health Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference76 articles.

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2. Progesterone action in breast, uterine, and ovarian cancers

3. N. Howlader A. M. Noone M. Krapcho D. Miller K. Bishop S. F. Altekruse C. L. Kosary M. Yu J. Ruhl Z. Tatalovich A. Mariotto D. R. Lewis H. S. Chen E. J. Feuer K. A. Cronin Eds. SEER Cancer Statistics Review 1975-2013 (National Cancer Institute. Bethesda MD 2013) vol. based on November 2015 SEER data submission; http://seer.cancer.gov/csr/1975_2013/.

4. Progesterone-regulated genes in the ovulation process: ADAMTS-1 and cathepsin L proteases

5. The Chicken Progesterone Receptor A and B Isoforms Are Products of an Alternate Translation Initiation Event

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