Dysregulated RasGRP1 Responds to Cytokine Receptor Input in T Cell Leukemogenesis

Author:

Hartzell Catherine1,Ksionda Olga1,Lemmens Ed1,Coakley Kristen1,Yang Ming2,Dail Monique3,Harvey Richard C.4,Govern Christopher2,Bakker Jeroen1,Lenstra Tineke L.1,Ammon Kristin3,Boeter Anne1,Winter Stuart S.5,Loh Mignon3,Shannon Kevin3,Chakraborty Arup K.26789,Wabl Matthias10,Roose Jeroen P.1

Affiliation:

1. Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.

2. Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

3. Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94143, USA.

4. Department of Pathology, University of New Mexico School of Medicine, MSC 10 5590, Albuquerque, NM 87131, USA.

5. Department of Pediatrics, University of New Mexico School of Medicine, MSC 10 5590, Albuquerque, NM 87131, USA.

6. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

7. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

8. Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

9. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

10. Department of Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.

Abstract

Understanding the signaling mechanisms that can lead to T cell leukemia may enable personalized therapies.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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