Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells-Reference-Cited by-同舟云学术

Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells

Published:2020-01-14 Issue:614 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Karathanasis Christos¹^ORCID,Medler Juliane²^ORCID,Fricke Franziska¹,Smith Sonja³^ORCID,Malkusch Sebastian¹^ORCID,Widera Darius⁴^ORCID,Fulda Simone³⁵⁶,Wajant Harald²,van Wijk Sjoerd J. L.³^ORCID,Dikic Ivan⁷⁸^ORCID,Heilemann Mike¹^ORCID

Affiliation:

1. Institute of Physical and Theoretical Chemistry, Goethe University, Max-von-Laue-Strasse 7, 60438 Frankfurt am Main, Germany.

2. Division of Molecular Internal Medicine, Department of Internal Medicine II, University Hospital Würzburg, Auverahaus, Grombühlstrasse 12, 97080 Würzburg, Germany.

3. Institute for Experimental Cancer Research in Paediatrics, Goethe University, Komturstrasse 3a, 60528 Frankfurt am Main, Germany.

4. Stem Cell Biology and Regenerative Medicine Group, School of Pharmacy, University of Reading, RG6 6UB Reading, UK.

5. German Cancer Consortium (DKTK), Heidelberg, Germany.

6. German Cancer Research Centre (DKFZ), Heidelberg, Germany.

7. Institute of Biochemistry II, Goethe University Medical School, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.

8. Buchmann Institute for Molecular Life Sciences (BMLS), Goethe University, Max-von-Laue-Strasse 15, 60438 Frankfurt am Main, Germany.

Abstract

Ligand binding triggers the oligomerization of TNFR1 monomers and dimers into trimers and higher-order oligomers.

Funder

Deutsche Forschungsgemeinschaft

Dr. Eberhard and Hilde Rüdiger Foundation

Bundesministerium für Bildung und Forschung

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference42 articles.

1. The signaling adaptors and pathways activated by TNF superfamily

2. Signalling pathways of the TNF superfamily: a double-edged sword

3. The TNF and TNF Receptor Superfamilies

4. Checkpoints in TNF-Induced Cell Death: Implications in Inflammation and Cancer

5. TNFR1-induced activation of the classical NF-κB pathway

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